CAS No.: | 138112-76-2 |
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Formula: | C15h17no2 |
Grade: | Food Grade B |
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Product Name | Hot Sale Pharmaceutical Nootropics Agomelatine Raw Material Powder CAS 138112-76-2 for Anti-Depression |
Appearance | White powder |
Molecular formula | C15H17NO2 |
Keywords | Material Agomelatine;Bulk Agomelatine;Raw Powder Agomelatine |
Shelf Life | 24 months when properly stored |
Storage | Keep in a cool, dry, dark location |
Agomelatine has shown antidepressant effects in a variety of animal models of depression.The mechanism of antidepressant may be related to the increase of neuronal plasticity and neuronal proliferation in hippocampus.
Immunostaining was used to measure the proliferation, regeneration and death of nerve cells in the brain of adult rats. It was found that long-term (3 weeks) administration of agomelatine increased the proliferation and regeneration of neurons in the ventral dentate gyrus of the hippocampus, which is involved in emotional response.No similar effect was observed at acute or subacute administration (4 h or 9 weeks).